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Wael Abou El-Kheir

Immunology Department, Military Medical Academy. Cairo, Egypt.

Title: Autologous Adipose Derived Stem Cell Versus Platelet Rich Plasma Injection In The Treatment Of Androgentic Alopecia: Efficacy, Side Effects And Safety

Biography

Biography: Wael Abou El-Kheir

Abstract

BACKGROUND   

Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment were recently introduced as an alternative potential therapeutic application for hair growth.

OBJECTIVE   

The aim of this study was to assess the efficacy side effects and safety of AT-ASCs and PRP in the treatment of androgentic alopecia.

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PATIENTS AND METHODS

Sixty randomized patients were treated by PRP, and AT-ASCs. Each patient was evaluated, and each lesion was treated by those modalities,   patients received three sessions with one month interval  for 3 months, follow up after 3 months.

RESULTS  

A highly significant improvement <0.001  in terminal hair count of AT-ASCs group evaluated by videodermoscopy assessment of AGA. That were confirmed by highly significant improvement in inter-mediate hair count and mean caliber (<0.001) associated with high incidence of side effects especially headache and erythema.

In contrast, PRP group showed  significant improvement 0.037  in terminal hair count and non signanficant improvement in inter-mediate hair count and of  mean caliber with minimum side effects.

AT-ASCs showed a significant improvement in terminal hair count than PRP, Highly significant improvement in Inter-mediate hair count and hair caliber.

Also, side effects of AT-ASCs showed highly significant pain, headache and erythema but no serious adverse events.

CONCLUSION

Our study suggests that the There was significant improvement in AGA after PRP and  highly significant after AT-ASCs therapy with significant difference of ADSC in terminal hair count and highly significant in caliber. Both modalities could effectively and safely be used to treat AGA.